Kim JY et al. “Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a
randomized, double-blind, placebo-controlled trial” Nutr J. 2012;11(1), 1-9.
The beneficial effect of Korean red ginseng (KRG) on antioxidant enzyme activity:
Oxidative stress describes a set of intracellular or extracellular conditions that lead to the chemical or metabolic generation of reactive
oxygen/nitrogen species. The reported health benefits of Korean red ginseng (KRG) include antioxidant, antitumor, antimutagenic, and
immunomodulatory activities; however, the effects on oxidative stress have not yet been evaluated. Therefore, we assessed the effect of
KRG on antioxidant enzymes and oxidative stress markers in humans.
Results:
KRG supplementation improved biomarkers of oxidative stress, as evidenced by decrease plasma oxidized LDL, attenuated lymphocyte DNA
damage and increase plasma antioxidant enzyme activity in healthy participants.
Conclusion::
KRG supplementation may attenuate lymphocyte DNA damage and LDL oxidation by upregulating antioxidant enzyme activity.
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