Heo JH et al. “Improvement of cognitive deficit in Alzheimer’s disease patients by long term treatment with Korean red ginseng” J Ginseng Res.
2011;35(4):457-461.



The effect of Korean red ginseng (KRG) on Alzheimer’s disease (AD):

In spite of enormous research efforts, only a few symptomatic treatment options currently exist for dementia. Ginseng has been proven to
have effects on cognitive functions in healthy individuals. However, only a few studies have shown effects of KRG on dementia. The goals
of this study were: 1) to further clarify the long-term efficacy of KRG as an adjuvant therapy to conventional anti-dementia medications in
patients with AD and 2) to monitor the cognitive changes during the extended follow-up duration.



Conclusion

The study results suggest that Korean red ginseng treatment is both safe and feasible,
and is effective for the long-term management of Alzheimer’s disease patients.


View Infographic

View Clinical Data

Kim JY et al. “Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a
randomized, double-blind, placebo-controlled trial” Nutr J. 2012;11(1), 1-9.



The beneficial effect of Korean red ginseng (KRG) on antioxidant enzyme activity:

Oxidative stress describes a set of intracellular or extracellular conditions that lead to the chemical or metabolic generation of reactive
oxygen/nitrogen species. The reported health benefits of Korean red ginseng (KRG) include antioxidant, antitumor, antimutagenic, and
immunomodulatory activities; however, the effects on oxidative stress have not yet been evaluated. Therefore, we assessed the effect of
KRG on antioxidant enzymes and oxidative stress markers in humans.


Results:

KRG supplementation improved biomarkers of oxidative stress, as evidenced by decrease plasma oxidized LDL, attenuated lymphocyte DNA
damage and increase plasma antioxidant enzyme activity in healthy participants.


Conclusion:

KRG supplementation may attenuate lymphocyte DNA damage and LDL oxidation by
upregulating antioxidant enzyme activity.


View Infographic

View Clinical Data

Ahn CM et al. “Red Ginseng Extract Improves Coronary Flow Reserve and Increases Absolute Numbers of Various Circulating Angiogenic Cells in Patients with
First ST-Segment Elevation Acute Myocardial Infarction” Psychother Res. 2011;25:239-245.



The effect of Korean red ginseng (KRG) on coronary flow reserve:

Baseline coronary flow reserve (CFR) has been used as a predictor of improvement in left ventricular function after AMI (acute myocardial
infarction) however, baseline and 8-month follow-up CFR values have never been compared in ST-elevation AMI patients after KRG extract
administration. Therefore, in this study, the effects of red ginseng extract on circulating angiogenic cell mobilization and improvement of
microvascular integrity were compared in ST-segment elevation AMI patients during an 8-month follow-up period.


Results:

Improvement of coronary flow reserve and increase of circulating angiogenic cells
KRG improved CFR in first ST-elevation and increased circulating angiogenic cell mobilization and decreased inflammation in AMI patients during the
8-month follow-up.


Conclusion:

3g /day of KRG for 8 months is an effective and safe treatment for first ST-elevation AMI
patients, possibly by restoration of microvascular function.


View Infographic

View Clinical Data

Yeo, HB et al. “Effects of Korean red ginseng on cognitive and motor function: a double-blind, randomized, placebo-controlled trial” J Ginseng Res. 2012;36(2):190.



The effect of Korean red ginseng (KRG) on cognitive function:

There is some evidence from animal studies that ginseng has a beneficial effect on cognitive performance. KRG was shown in one study
to significantly reduce the P300 latency, suggesting that it can directly modulate cerebro-electrical activity. The current study used the
P300 event-related potential (ERP) and the neurocognitive function test to investigate the effect of KRG on cognitive performance.


Results:

The decreased P300 latency may indicate an improvement in cognitive function, especially in association with attention allocation, immediate
memory and behavior reaction time.


Conclusion:

The KRG group showed a decreased P300 latency in the central area, suggesting that the
decreased latency in ERP after KRG supplementation is associated with improved
cognitive function.


View Infographic

View Clinical Data

Jeong HG et al. “Effect of Korean Red Ginseng as an adjuvant treatment for women with residual symptoms of major depression” Asia Pac Psychiatry.
2015;7(3):330-336.



The effect of Korean red ginseng (KRG) on depression:

Depression is considered as a serious illness, but can be cured as various pharmacological agents become more readily available. Ginseng
has shown potential antidepressant effects in some animal studies and in patients with stress-related somatic symptoms. Therefore,
we investigated the effectiveness and tolerability of KRG adjuvant treatment in patients with residual symptoms of major depression.


Results:

The subjects reported significant decrease in depressive symptoms
on DRSS, MADRS and CGI-S and in somatic symptoms on DSSS over the
eight-week study period of taking Korean red ginseng.

Conclusion:

These study results suggest that Korean red ginseng is effective and safe in patients
experiencing residual symptoms of depression, indicating the feasibility of Korean red
ginseng as an alternative treatment option for patients with depression and other
related disorders.


View Infographic

View Clinical Data

Yun TK et al. “Non-organ specific preventive effect of long-term administration of Korean red ginseng extract on incidence of human cancers” J Med Food.
2010;13(3):489-494.



The effect of Korean red ginseng (KRG) on chronic atrophic gastritis:

Previously, two case-control studies and a cohort study strongly suggested that Panax ginseng C.A. Meyer exerted non–organ-specific
preventive effects against cancer. In the present study, the cancer preventative effect of P. ginseng C.A was tested against gastric cancer,
which has a high incidence rate in many Asian countries. Chronic atrophic gastritis was chosen because the risk of stomach cancer
occurrence in this disease was 5.73-fold higher than that of normal individuals.



Conclusion:

The non-organ-specific cancer preventive effect of Korean red ginseng was confirmed
clinically even in gastric cancer-prone patients.


View Infographic

View Clinical Data

Kim NR et al. “Effect of Korean Red Ginseng Supplementation on Ocular Blood Flow in Patients with Glaucoma” J Ginseng Res. 2010;34(3):237-245.



The effect of Korean red ginseng (KRG) on glaucoma:

Glaucoma, a leading cause of blindness in the world, is a group of diseases characterized by progressive optic neuropathy with a particular
pattern of visual field loss. Improving ocular blood flow may help the treatment of glaucoma and favorable effects of ginseng roots on
circulation have been reported. In the present study, we assessed the effect of KRG ingestion on ocular blood flow in patients with
open-angle glaucoma.

Conclusion:
KRG ingestion appears to improve retinal peripapillary blood flow in patients with open-angle glaucoma (in the temporal peripapillary areas),implying that KRG ingestion might be helpful for glaucoma management.


View Infographic

View Clinical Data

Bang H et al. “Korean red ginseng improves glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed type 2
diabetes mellitus” J Med Food. 2014;17(1):128-134.


The effect of Korean red ginseng (KRG) on type 2 diabetes mellitus (T2DM):

Until now, there have been few clinical studies on the efficacy of red ginseng extract or powder for blood glucose control, and past studies
mostly included people with T2DM or normal blood glucose levels. This study was designed to evaluate the effect of KRG supplementation
on glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed with T2DM and to establish
clinical evidence of the glucose control effect of KRG.


Conclusion:

The study results indicate that Korean red ginseng supplementation has potential for improving glucose control along with improvements in glucose-related biomarkers.


View Infographic

View Clinical Data

Oh GN et al. “Efficacy of Korean Red Ginseng in the Treatment of Alopecia Areata” J Ginseng Res. 2012;36(4):391-395.



The effect of Korean red ginseng (KRG) on alopecia areata (AA):

AA is an autoimmune disease that can affect any hair-bearing area. Though many therapeutic modalities have been used to treat AA, none of these agents is definitely curative or preventive alone. In Korea, KRG is well known to effective for prevention of hair loss and growth of
hair. However, there are still no reports of the efficacy of KRG in AA using medical engineering techniques. Thus, the authors studied hair
growth efficacy and safety of KRG in AA.



Results:
This study results suggest that treatment with KRG can result in improved hair regrowth in AA patients.



Conclusion:

This study proved the efficacy of KRG in the treatment of AA, recommending KRG as a
useful complementary food for management of AA.




View Infographic

View Clinical Data

Choi SH et al. “Effects of complementary combination therapy of Korean red ginseng and antiviral agents in chronic hepatitis B” J Alt Compl Med.
2016;22(12):964-969.



The effect of Korean red ginseng (KRG) on chronic hepatitis B (CHB):

CHB management is commonly targeted at reducing viral replication. However, the currently available antiviral therapies are associated with
some problems, including resistance and numerous adverse effects. Ginseng has been reported to be effective for treating viral infections
such as influenza and human immunodeficiency virus. This study investigated the effects of KRG together with antiviral agents in CHB.


Conclusion:

The decrease of non-invasive fibrosis serologic markers after Korean red ginseng administration in this study indicates the possibility of Korean red ginseng as a complementary
therapy for chronic hepatitis B.


View Infographic

View Clinical Data

Cho YK et al. “Effect of Korean red ginseng intake on the survival duration of human immunodeficiency virus type 1 patients” J Ginseng Res. 2017;41:222-226.


The effect of Korean red ginseng (KRG) on human immunodeficiency virus (HIV):

Progressive loss of CD4+ T cells is the hallmark of HIV infection, and is accompanied by chronic inflammation and chronic immune
hyperactivation. Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with
KRG can also enhance survival duration in patients with HIV-1 infection.



Conclusion:

This study results show that even moderate Korean red ginseng doses for a sufficient
period can improve survival duration in HIV-1 patients not receiving HAART and that
efficacy improves with cumulative intake.


View Infographic

View Clinical Data

Cha TW et al. “Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA2 activity and lysophosphatidylcholines and
increased dihydrobiopterin level in prehypertensive subjects” Hypertension Res. 2016;39:449-456.



The effect of Korean red ginseng (KRG) on hypertension:

Although hypertension is a known risk factor for atherosclerosis and cardiovascular disease the mechanisms underlying this relationship
are unclear. Previous studies evaluating the physiological effects of ginseng suggest that red ginseng is more beneficial than other types of
ginseng on circulating metabolic profiles. We evaluated the effects of KRG consumption on blood pressure and the fasting plasma
metabolome.


Conclusion

This study results indicate that the blood pressure-lowering effect of Korean red ginseng
is associated with decreased Lp-PLA2 and lysoPCs and increased dihydrobiopterin
levels in prehypertensive subjects.


View Infographic

View Clinical Data

Lee SJ et al. “Efficacy of Korean red ginseng supplementation on eradication rate and gastric volatile sulfur compound levels after Helicobacter pylori eradication
therapy” J Ginseng Res. 2010;34:122-131.


The effect of Korean red ginseng (KRG) on Helicobacter pylori (H. pylori) eradication:

Previous studies have suggested that KRG 1) inhibits H. pylori colonization, 2) exhibits antioxidative and anti-inflammatory effects, 3)
provides efficient restorative action, 4) inhibits expression of genes associated with generation of volatile sulfur compounds, and 5)
increases eradication rates. This study was performed to evaluate whether PPI-based triple therapy with KRG can enhance H. pylori
eradication and reduce levels of halitosis-associated volatile sulfur compounds.



Conclusion:

Korean red ginseng along with triple therapy increased the H. pylori eradication rate and
led to significant reductions in VSC levels, suggesting the usefulness of Korean red
ginseng in combating H. pylori infection (treatment of H. pylori-associated halitosis).



View Infographic

View Clinical Data

Hyun, SH et al. “Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial” J Ginseng Res.
2021;45(1):191-198.



The immunoactivity of Korean red ginseng (KRG) for healthy controls:

Natural foods come up in the discourse around enhancing bodily functions, one of which is ginseng. Most clinical studies of immune
responses activated by KRG have been conducted exclusively in patients. However, there is still a lack of clinical research on immune
boosting benefits of KRG for healthy persons. This study aims to confirm how KRG boosts the immune system of healthy subjects


Results:

The significantly increased T cell, B cell and WBC levels confirmed that KRG increases immunity not only for cancer patients but also for healthy subjects with reduced immunity.


Conclusion:

Through 8-week intake test and subsequent analysis, KRG was proven its safety and
immune boosting activity. KRG increases the number of immune cells to help improve
immunity when consumed by healthy adults with slightly downregulated immunity as an
excellent immunopotentiator.


View Infographic

View Clinical Data

Abdel-Wahhab MA et al. “Therapeutic effects of Korean red ginseng extract in Egyptian patients with chronic liver disease” J Ginseng Res. 2011;35(1):69-79.



The effect of Korean red ginseng (KRG) on hepatocellular carcinoma (HCC):

HCC is the fifth most common malignancy in the world and complicates liver cirrhosis related to hepatitis C virus in many cases. Several
studies have found that the antitumor activity of a novel ginseng saponin metabolite (IH-901) is attributable to the induction of apoptosis.
The aim of the current study was to evaluate the therapeutic effects of KRG extract in Egyptian patients with chronic liver diseases.


Results:

This study results showed that the medical therapy alone
failed to normalize the liver enzymes or decrease the virus
concentration. Korean red ginseng administration induced
a significant improvement in liver function tests,
decreased the tumor marker levels, and decreased the
viral titers in HCV patients.


Conclusion:

The results of the current study indicate that Korean red ginseng could act as liver cancer
preventative as well as an antiviral agent against HCV.


View Infographic

View Clinical Data

Kim, SY et al. “Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind
randomized controlled trial” Menopause. 2012;19(4):461-466.



The effect of red ginseng (RG) on menopausal symptoms:

Red Ginseng has been widely used to treat diseases such as cancer and cardiovascular disease (CVD) in East Asian countries. Previous
studies have shown that Red Ginseng is effective against the psychological and emotional symptoms that are common in postmenopausal
women. The aim of this study was to evaluate the effects of Red Ginseng on menopausal symptoms and cardiovascular risk factors in
postmenopausal women.


Results:

The significantly increased T cell, B cell and WBC levels
confirmed that KRG increases immunity not only for cancer
patients but also for healthy subjects with reduced immunity.


Conclusion:

The Red Ginseng could be an attractive herbal dietary supplement for relieving menopausal
symptoms and conferring favorable effects on markers of cardiovascular disease
in postmenopausal women.


View Infographic

View Clinical Data

Kwon DH et al. “Efficacy of Korean Red Ginseng by Single Nucleotide Polymorphism in Obese Women: Randomized, Double-blind, Placebo-controlled Trial” J
Ginseng Res. 2012;36(2):176-189.



The effect of Korean red ginseng (KRG) on obesity:

Obesity is caused by the imbalance of energy metabolism. KRG or ginseng has been proven to be very effective for improving obesity and
abnormal metabolism in animal studies and clinical studies. These effects of KRG and ginseng on the treatment of obesity can be thought
to be greater in the obesity caused by reduced energy metabolism. This study examined the effects of KRG on obese women and aimed to
confirm that the effects of KRG on obesity differ dependently on a gene.


Results:

KRG is more effective for improving the secondary issues of
the quality of life derived from obesity rather than having direct
effects on the obesity-related anthropometric assessment and
blood test indices.



Conclusion:
This study tried to examine the differences of the effects of KRG on the obesity indices by gene mutation.


KRG is more effective for improving the secondary issues of the quality of life derived from obesity rather than having direct effects on the obesity-related anthropometric assessment and blood test indices.




View Infographic

View Clinical Data

Park HJ et al. “Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: A Randomized Placebo-Controlled, Double-Blind Clinical
Study” Chin J Integr Med. 2016;22(7):490-495.


The effect of Korean red ginseng (KRG) on male infertility:

Many empirical treatments have been used to improve the quality and concentration of sperm, although good results have not been
achieved. Several studies have also reported that ginseng improves spermatogenesis in animals. These effects were probably caused by
anti-oxidant and anti-aging actions, as well as modulation of the hypothalamuspituitary-testis axis. This study was to investigate the
effects of KRG on semen parameters in male infertility patients.


Results:

KRG-treated groups with or without varicocelectomy showed
significantly improved semen parameters in terms of sperm
concentration, viability, motility, and morphology.


Conclusion

As the treatment with KRG for 12 weeks enhanced spermatogenesis, KRG may be a useful
agent for the treatment of male infertility.




View Infographic

View Clinical Data

Kim H et al. “The beneficial effect of Korean red ginseng extract on atopic dermatitis patients” Ann Dermatol. 2018;30(3):304-308.



The effect of Korean red ginseng (KRG) on atopic dermatitis (AD):

AD is a chronic or chronically relapsing, eczematous, severely pruritic inflammatory skin disorder. KRG has been shown previously to exhibit
diverse biological effects including anti-inflammatory and antipruritic effects in a murine model. We aimed to investigate the beneficial
effects of KRG on AD patients, to determine whether there was improvement in disease severity, skin barrier function, pruritus and sleep
disturbance relief.


Results:

Korean red ginseng not only improves the general well-being of the
patients, but also restores the skin barrier function
through reduction of TEWL.


Conclusion:

This study suggest that KRG can be safely used as a supplement remedy leading to
clinical improvement of AD, can improve overall quality of life, and has potential for
further development.


View Infographic

View Clinical Data

Han HJ et al. “Effects of red ginseng extract on sleep behaviors in human volunteers” J Ethnopharmacol. 2013;149:597-599



The effect of Korean red ginseng (KRG) on sleep:

The ginseng root has been traditionally used as a sedative in oriental countries. However, the condition “ginseng abuse syndrome”, was
coined as a result of a study of people who had been using a variety of ginseng preparations. However, we reported that administration of
KRG increased rapid eye movement and non rapid eye sleep via GABAergic systems in animals. Therefore, this study was performed to
investigate KRG affects sleeping behaviors in human volunteers.


Results:

Administration of Korean red ginseng significantly reduced the total wake time and increased the sleep efficiency, while reducing N1 and improving REM sleep.


Conclusion:
From these results, it is presumed that KRG intake does not interfere with sleep, but rather
improves the quality of sleep, thus having beneficial effects on sleep disturbed subjects.


View Infographic

View Clinical Data

Sung, WS et al. “Efficacy of Korean red ginseng (Panax ginseng) for middle-aged and moderate level of chronic fatigue patients: A randomized, double-blind,
placebo-controlled trial” Complement Ther Med. 2020;48, 102246.



The effect of Korean red ginseng (KRG) on chronic fatigue (CF):

CF is unexplained fatigue lasting more than 6 months. Several studies demonstrated the role of oxidative stress in CF and suggested the
administration of antioxidants as a potential treatment. KRG is known to have higher anti-fatigue substance than white ginseng. The purpose
of this study was to investigate the effect of KRG on CF by various measurements and objective indicators.


Results:

KRG provided the objective evidence of fatigue-related measurement and the therapeutic potential for middle-aged individuals with moderate fatigue.


Conclusion:

KRG demonstrated its safety and efficacy for patients with chronic fatigue, suggesting its
potential for treating a subset of patients with chronic fatigue (moderate or idiopathic
chronic fatigue.


View Infographic

View Clinical Data

Chung IM et al. “Korean red ginseng improves vascular stiffness in patients with coronary artery disease” J Ginseng Res. 2010;34(3):212-218.


The effect of Korean red ginseng (KRG) on coronary artery disease (CAD):

Endothelial dysfunction is regarded as not only the earliest manifestation of atherosclerosis but also as a prognostic factor for adverse
cardiovascular events. KRG has diverse effects on the vasculature, improving endothelial function. The aim of this study was to determine
whether KRG has an effect on arterial stiffness and cardiovascular risk factors in patients with CAD.


Results:

Korean red ginseng treatment for 10 weeks reduced the systolic
blood pressure and the vascular stiffness in the central aorta and
peripheral muscular arteries, probably via the inhibition of ROCK activity
in patients with coronary artery disease.


Conclusion:

The Korean red ginseng-induced effects in this study suggest the need of further study for
understanding the pharmacological effects of Korean red ginseng on the progression of
atherosclerotic plaque formation and the prevention of acute coronary syndrome in
patients with coronary artery disease.


View Infographic

View Clinical Data